He was awarded F31 and F32 individual fellowships from the NIH and selected in the first wave of K99/R00 awards. November 9, 2021. . Your gift helps provide better care, investigate and develop new therapies, and train the next generation of movement disorders specialists. Liddles co-investigators include Dukes Andrew West, PhD, Pharmacology; Timothy Sampson, PhD, Emory University; Mal Gmez Tansey, PhD, University of Florida; and Haydeh Payami, PhD, University of Alabama at Birmingham. Fox Foundation for Parkinson's Research, the . But much more research is needed before researchers can say for sure. Burton Mail - read now online on YUMPU News Magazine flat rate Subscription Read digitally YUMPU News digital subscription - 30 days free trial! @2023 Duke University and Duke University Health System. Current treatments like L-DOPA can relief the disease symptoms, but it has side effects called L-DOPA induced dyskinesia (LID). One immediately came to mind: mad cow disease. He has been named to "Best Doctors in America." Dr. Stacy is a fellow in the American Academy of Neurology, and sits on the Board of Directors of WE MOVE, a not-for-profit foundation dedicated to education in Movement Disorders. Parkinson's disease is a progressive neurological disorder that results when some of the nerve centers in the brain lose their ability to regulate the movement of muscles. Dukes coordinating lead investigators for the two research projects are Nicole Calakos, MD, PhD, Lincoln Financial Group Distinguished Professor of Neurobiology and Neurology, and Rodger Liddle, MD, Professor of Medicine. If your house is built on a strong base, then it might last longer. 2012-13 RUTGERS TEAM ROSTERS Numerical Roster No. The three-year, $300,000 award will support Tadross's continued work to explore the neurological and biomolecular roots of Parkinson's disease using his novel drug targeting system. Calakos says that when she first met Eroglu, she was intrigued by her idea that since astrocytes are involved in sculpting thelanguage of neurons, perhaps they play a role in the events that can lead to disease. We are seeing aging as a part of development, Eroglu says. The Book of the Courtier (1528) is a series of fictional conversations by courtiers of the Duke of Urbino that takes place in 1507, while Castiglione was himself attach to the Duke.. The first signs are problems with movement. We expect the student to have an academic background in biology, biochemistry, pharmacology, chemistry or related area. Seelos Therapeutics licensed gene therapy product SLS-004 from Duke University to treat patients with Parkinson's Disease. Assessment of the fellows progress occurs through weekly meetings with the fellowship director, and through structured feedback given quarterly. Bohrquez, who is now an assistant professor of medicine (Gastroenterology) and neurobiology at Duke, discovered in his laboratory that these cells form a neural circuit conveys signals from nutrients in the gut to the brain in milliseconds. If we can figure out the weakest link, then we could concentrate on solving that.. He is 49 years old. 1.75 m). 1 morning show, Good Day NY, might also be the fittest man on television. Now, as our newest PA, shes's helping patients with a variety of headaches at our Neurological Disorders Clinic at Morreene Road. Acute Pancreatitis. Yes. 1 sp. Parkinson's disease (PD) is movement disorder of the nervous system that gets worse over time. By Angela Spivey / Photos by Alex Boerner More than 10 million people worldwideabout 1 percent of people over age 60live with Parkinson's disease. But the cell that the team saw under the microscope that day was different from all the others theyd previously seen hanging out in the gut. Important In addition to forwarding the appropriate applications materials, please apply via sfmatch at www.sfmatch.org. And I go Parkinsons disease!? dukehealth.org. We will consider applicants with J1 Visas, and other visas may be considered on a case-by-case basis. Currently, there have been no reports of him being sick or having any health-related problems. Read more about our diversity and inclusion efforts across the Department here. From there, the possibilities for new research ventures seemed endless. He is alive and in good health. Duke Pancakes for Parkinson's is a philanthropic group whose main focus is to raise money and support for the fight against. One step at a time: Under Hood's leadership, the Michael J. Other associated features are a loss of smell, sleep dysfunction, mood disorders, excess salivation, constipation, and excessive periodic limb movements in sleep (REM behavior disorder). dukehealth.org. Patients experienced movement deficits, memory disturbances and cognitive impairments. Charles Parkinson is a son of the late Professor C Northcote Parkinson, the naval historian and author of 'Parkinson's Law'. @2023 Duke University and Duke University Health System. Duke is a man of above-average stature who stands at a height of 5 ft 9 in (Approx. The center is located at the Duke Neurology Morreene Road clinic. Using a computer-aided virtual screening platform, we screened millions of compounds to find hits that can potentially bind to the D1R. His laboratory studies how the gut senses the caloric value of nutrients to influence the choice of food we eat. The awards from theAligning Science Across Parkinsons (ASAP) initiativeposition Duke as a national leader in understanding the origins and development of this devastating movement disorder. Call 919-668-7600 to schedule an appointment. Acute Gastrointestinal Bleeding - 02/22/2022. Mike Wankum WCBV, Bio, Wiki, Age, Wife, Wedding, Son, Racing, Salary, and Net Worth, Mike Lynch WCVB, Bio, Wiki, Age, Height, Wife, WCCO, Salary, and Net Worth, Copyright 2023 | WordPress Theme by MH Themes, List of States in the US, Alphabetical list of States in the U.S., and Abbreviation of States in United States. Succeeding where earlier attempts have failed, the method promises to provide new insights into why deep brain stimulation works and ways in which it can be improved on a patient-by . The student will get lab experience in computer-aided drug discovery and drug screening, which will be extremely valuable if the student wants to further pursue an advanced degree in MD, PhD or MD-PhD. The Parkinson's Disease and Movement Disorders fellowship at the Duke University School of Medicine is designed to produce the next generation of physician-scientists. The Chan Zuckerberg grant is an opportunity to get together as a formal team. 2012-13 SEASON OUTLOOK The Rutgers women's basketball team opens the 2012-13 season with a well-crafted balance of veteran leadership and youthful enthusiasm, a mix that most programs strive for. In addition to her clinical insight, Calakos brings expertise in electrophysiologyreal-time recording and observation of electrical signals coming from brain cells. Hematologic Malignancies and Cellular Therapy, Pulmonary, Allergy, and Critical Care Medicine, Our Commitment to Diversity and Inclusion in Training, Aligning Science Across Parkinsons (ASAP) initiative. Hours per week. Approximately five inches long, with an elongated toe bed and a skinny ankle, it almost resembles the snout of a crocodile. Duke's average Salary is $83,201 . . Biomedical engineers at Duke University have used deep brain stimulation based on light to treat motor dysfunction in an animal model of Parkinson's disease. All rights reserved. Lang: en Joseph "Duke" Castiglione Jr. (born June 21, 1973) is an American news anchor for WCVB-TV Boston's NewsCenter 5 weekend newscasts. Astrocytes from the Greek astron, meaning "star"have traditionally been thought of as support cells. Collaboration with Cell Biology (Cagla Eroglu, PhD) provides access to cutting-edge PD disease mechanism research involving glia, and incoming fellows will further benefit from major growth in Parkinsons disease and neurodegeneration research spearheaded by Dukes Center for Neurodegeneration and Neurotherapeutics led by Al LaSpada, MD, PhD a world expert in trinucleotide repeat disorder mechanisms. Our specialized clinical pharmacist is available to help you manage your medications, minimize side effects, and reduce medication costs. For years Liddle has studied how hormones in the gut work. Opportunities exist for basic, translational, and clinical research, and our program has long enjoyed robust working relationships with the Departments of Neurosurgery, Neurobiology, Biomedical Engineering, Psychiatry, Physical Therapy, and Radiology. Advanced Practice Providers Residency Program, Underrepresented in Neurology Tele-Shadowing Experience, Epilepsy, Sleep, and Clinical Neurophysiology, Parkinson's Disease And Movement Disorders. Top 5 des morts les plus improbables de lhistoire, new construction homes orlando under $250k, frases para padres que no se preocupan por sus hijos, castlevania: aria of sorrow best equipment, radney funeral home saraland al obituaries. Our commitment to excellent care includes an interdisciplinary care team approach, and fellows benefit from weekly interdisciplinary meetings with PT, OT, speech therapy, pharmacy, and social work. Importance: Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, and clinical data. Dukes average Salary is $83,201 per year. Depending on whom you ask, it's classified as an atypical parkinsonism disorder, a non-Alzheimer's dementia, or a type of frontotemporal degeneration. The Parkinson's Foundation recognizes our Movement Disorders Clinic as one of 37 Centers of Excellence in the U.S. A Parkinson's Foundation Center of Excellence is a medical center with a specialized team of neurologists, movement disorder specialists, physical and occupational therapists, mental health professionals and others who are up to date on the latest PD medications, therapies and research to provide the best care. Physical and Occupational Therapy Prusiner, however, had another suggestion: Parkinsons disease. Duke Castiglione Salary. @2023 Duke University and Duke University Health System. The findings provide strong evidence that Parkinson's disease has an important genetic component and is not caused exclusively by environmental . DaTscan Every step has been one surprise after another.. In a stroke of luck, Prusiner was already planning to give a talk at Duke, so Liddle set up a meeting with him during his visit. The Duke Neurology Department recognizes that diversity is a necessary component of its mission ofworld-class patient care, education, and research. These changes can cause involuntary or excessive movements, called hyperkinesias. We couldnt contain our excitement, said Bohrquez. This is an exciting moment for Duke, and an exciting moment for anyone with or affected by Parkinsons disease, Calakos said. Collaboration with Cell Biology (Cagla Eroglu, PhD) provides access to cutting-edge PD disease mechanism research involving glia, and incoming fellows will further benefit from major growth in Parkinsons disease and neurodegeneration research. And much like his DC Comics counterpart, you'd never be able to guess that underneath the suit and tie lies an insanely ripped, athletic physique. From there, the possibilities for new research ventures seemed endless. Each Center is required to meet rigorous care, clinical research, professional training, community education and outreach criteria. While medications, lifestyle modifications, and surgical procedures can help with symptoms, no therapies can stop or reverse the course of the disease. The Rush Parkinson's Disease and Movement Disorder Program is composed of a large and multidisciplinary team of clinical and laboratory researchers. Calakos co-investigators at Duke include Cagla Eroglu, PhD, Cell Biology; Scott Soderling, PhD, Cell Biology; Laurie Sanders, PhD, Neurology;and Michael Tadross, MD, PhD, Biomedical Engineering, and at Stanford University, Sergiu Pasca, MD. Professionalism and the Workplace Environment. And it had synaptic proteins. | One of our specialties at the Duke Department of Neurology is Parkinson's Disease & Movement Disorders. The two-year fellowship program emphasizes clinical experience in the first year, then transitions to a research focus in the second year. Melanogenesis is under complex regulatory control by multiple agents interacting via pathways Duke Castiglione joined Shaun Clancy for an episode of "Craic and the Bat" on Irish Baseball TV. medschool.duke.edu As nerve cells (neurons) in parts of the brain weaken, are damaged, or die, people may begin to notice problems with movement, tremor, stiffness in the limbs or the trunk of the body, or impaired balance. Castiglione was born on 21 June 1973 in the U.S. Castiglione has been named lead sports anchor at WCVB-TV (Channel 5), this happened slightly more than four months after longtime anchor Mike Lynch who previously announced in May his plan to retire after 37 years working for WCVB, moving from daily anchoring to working part-time as a special sports correspondent in August 2019. The Duke Neurology Department continued to build on its success in the second half of 2022. Corticobasal Degeneration (CBD) is the rarest of the four atypical parkinsonism disorders. Fellows will also participate in our educational outreach programs for patients and caregivers, and our comprehensive care model has been recognized with Center of Excellence recognition from the Parkinsons Foundation and the Huntingtons Disease Society of America. 380 Acp Ammo, Scientists have long accepted that this process was a conduit for the guts connection to the brain. Parkinson's Foundation Center of Excellence As noted above, fellows will work the Program Director and Division Chief during the first year to identify areas of interest and opportunities for collaboration, and a mentoring team will then be formed by year two. While the majority of our fellows clinical education occurs in the context of mentored patient care, fellows also participate actively in structured educational activities. Call (602) 795-8700. | NewYork-Presbyterian Komansky Children's Hospital 505 East 70th Street New York, NY 10032. duke.edu By Duke Today Staff At Loud and Proud, a monthly singing group for people with Parkinson's disease, patients combine discussion, speech exercises and singing to help keep their voices strong. If its found that they do, it could explain a lot. Bohrquez injected the virus and found just that - proof that there was a direct circuita neurocircuitbetween the gut surface and nerves. The epidemiological burden of parkinsonism increases with age. Besides, he is a recipient of the Associated Press award for both the Best Sports Show and two Black Journalist Awards due to his interviews with both Lawrence Taylor and Bernard King. Program Overview The two-year fellowship program emphasizes clinical experience in the first year, then transitions to a research focus in the second year. But the cell that the team saw under the microscope that day was different from all the others theyd previously seen hanging out in the gut. CBD. ) He is a man of above-average stature. Charles Parkinson (Author of The Duke and the Decoy) Duke students, faculty, researchers, clinicians and clinical care providers with an interest in advancing research and treatment of Movement Disorders are invitedto register to attend the first Meet & Greet co-hosted by the Neurology Department Division of Parkinson's Disease and Movement Disorders, and the Duke Center for Neurodegeneration & Neurotherapeutics. Theydiscovered this cell using a confocal microscope to examine the cells that line the gut wall of a mouse. 1 2 4 5 10 13 15 21 22 24 30 33 35 Name Jerome Seagears Dane Miller Myles Mack Eli Carter Mike Poole Malick Kone . As a designated Parkinsons Foundation Center of Excellence, Duke Health provides the highest level of diagnosis services andmedical and surgical treatments for people with Parkinson's disease. DURHAM, N.C. - Duke University Medical Center researchers have completed a genomic screen of Parkinson's disease suggesting that multiple genes are involved in the origins of the most common form of Parkinson's disease that occurs later in life. Dopamine neurons die as Parkinsons progresses and are a major cause of the slowed movements and other symptoms associated with the condition. duke.edu Newcastle Journal - read now online on YUMPU News Magazine flat rate Subscription Read digitally YUMPU News digital subscription - 30 days free trial! The division of Parkinson's Disease and Movement Disorders consists of an interdisciplinary group of neurological specialists who provide comprehensive specialty and subspecialty care. There are treatments that can help control symptoms, but there is no cure. Your provider may also suggest tests such as a dopamine transporter scan (DaTscan), MRI, genetic testing, or other blood tests. Cason B. Robbins, BS, of the Department of Ophthalmology at Duke University School of Medicine in Durham, North Carolina, lead author of the study, evaluated the retinal microvascular and choroidal structural changes in the eyes of patients with PD.1 . PARTICIPANTS: A total of 109 people with PD. Duke Castiglione Parkinson Disease | Health. Liddle, who sees patients with all sorts of gastrointestinal illnesses, has noticed in his own clinic that patients with Parkinsons disease often have constipation that develops before theyre ever diagnosed with the neurological disease. OCT/OCTA Ocular Biomarkers May Help Diagnose Parkinson Disease. medschool.duke.edu And when was the last time I took a vacation? The Parkinson's Foundation Helpline welcomes calls from people with Parkinson's disease, their families, friends and health care providers at 1-800-4PD-INFO (1-800-473-4636). Duke gets his wealth from his work as a Sports Anchor and Sports Columnist at WCVB-TV. Charles Parkinson is a son of the late Professor C Northcote Parkinson, the naval historian and author of 'Parkinson's Law'. 336-716-4101. Visit our event directory or find out more here about our monthly support groups. medschool.duke.edu Lindsay Key is the science writer forthe Duke University School of Medicine, and editor of the online storytelling magazine Magnify. There are treatments that can help control symptoms, but there is no cure. Joseph "Duke" Castiglione Jr. (born June 21, 1973) is an American news anchor for WCVB-TV Boston's NewsCenter 5 weekend newscasts. He reached out to colleagues in the Department of Neurobiology including Nicole Calakos, MD, PhD; Marguerita Klein; and Fan Wang, PhD, for guidance. 3,555 Followers, 450 Following, 952 Posts - See Instagram photos and videos from Duke Castiglione (@dukecastiglione) Visit IrishBaseball.org to learn more about the Irish Americ. He often brought his son, Duke, to work and now brings his grandchildren to the bond. Ongoing collaborations with the departments of Neurosurgery (Dennis Turner, MD, Nandan Lad, MD, PhD, and Derek Southwell, MD) and Biomedical Engineering (Warren Grill, PhD) provide unique opportunities for cutting-edge DBS research. Gilbert, AZ 85233. What is a gastroenterologist doing studying Parkinsons Disease? We can also help you develop successful strategies for communication and swallowing as your disease progresses, and help you learn to use augmentative and alternative communication, when appropriate. The awards from the Aligning Science Across Parkinson's (ASAP) initiative position Duke as a national leader in understanding . In 20132014, when comparing estimates among Canadians aged 85 years and older vs. those aged 40-44 years, the prevalence of the condition was 169 i times higher in the older age group (2.0% vs. 0.01%, respectively), while the incidence was 48 i times higher in the older age group . By day, Duke Castiglione is a mild mannered reporter. The discovery threw Liddle and Bohrquez for a loop. SportsCenter 5's Duke Castiglione argues that rookie quarterback Mac Jones won the starting position with the New England Patriots during the days veteran Cam Newton was barred from training camp . As a Parkinson's Foundation Center of Excellence, Duke is recognized for the expert care and comprehensive services our Duke movement disorder specialists provide to people with Parkinson's disease and related disorders. In his research, Liddle found that a hallmark of Parkinsons disease is Lewy bodies, which are abnormal aggregates of proteins that develop inside nerve cells. It's a chance for us all to compare notes, and I think this will accelerate all of our endeavors, La Spada says. In this review, we describe the routes of pesticide exposures occurring today, and summarize and evaluate the epidemiologic studies of pesticide-related . Our mission is to train physician-scientists with the skills necessary to expertly manage patients needs, while also advancing the scientific understanding of Parkinsons disease and other movement disorders. The student will be train for in vitro experiments including molecular biology, tissue culture,radioligand binding assay, cAMP assay, arrestin assay and confocal microscopy receptor translocation assay. This still-unpublished work laid the foundation for their proposal to the Chan Zuckerberg Initiative, which is bringing together experimental scientists from divergent fields to take a fresh look at the causes of neurodegenerative disorders. They communicate with its synapses, regulating blood flow and metabolism. 7200 W Bell Rd Ste F101. Duke University Medical Center Summary: . Many APDA-funded researchers have successfully leveraged pilot data to secure multi-million dollar grants through the National Institutes of Health and other funding partners. Duke is a 49-year-old who was born on June 21, 1973, in Marshfield, Massachusetts, in the United States. He named these cells neuropod cells. As a designated Center of Excellence, Duke has been recognized for offering the latest options to treat Parkinsons disease, helping set global care standards, participating in research to improve Parkinsons care, offering patient education programs, and training providers who want to treat Parkinsons disease. The two-year fellowship program emphasizes clinical experience in the first year, then transitions to a research focus in the second year. Learn about cutting-edge research, find clinical trials and support groups, connect with our faculty and more in our free quarterly newsletter. Please contact the Program Director Jeff Cooney, MD (jeffrey.cooney@duke.edu) with any questions. If the rabies virus spread onto an adjacent nerve, it would prove the gut cell was connected by a synapse with the nerve. And it had synaptic proteins. Each team selected for the Collaborative Research Network brings unique expertise and perspective to ASAPs mission of tackling key knowledge gaps in disease understanding through open science, said Ekemini Riley, PhD, ASAP Managing Director. Duke Castiglione Salary. DURHAM, N.C. -- Researchers at Duke University School of Medicine have been selected to lead two inter-institution team grants totaling $18 million to investigate Parkinson's disease. Sitting in her office, Eroglu picks up an orange plastic object that resembles a piece of coral, its tentacles branching this way and that. CCK travels through the bloodstream, stimulating digestion and letting the brain know whether the stomach is full and satisfied. BACKGROUND: People with Parkinson's disease (PD) have a progressive loss of function eventually leading to severe disability. If the cell in the gut was infected by rabies, it would imply that it was a nerve-like cell. Research and Clinical Trial Access @2023 Duke University and Duke University Health System. Helpline specialists answer calls about all aspects of Parkinson's disease (PD) and can help recommend specific Parkinson's Foundation resources that can help you. More than 10 million people worldwideabout 1 percent of people over age 60live with Parkinson's disease. He is alive and in good health. One of the major proteins found in Lewy bodies is called alpha-synuclein. Epidemiologic studies indicate that, despite premarket animal testing, current exposures are associated with risks to human health. Please fill out the Parkinsons and Movement Disorders Fellowship application (PDF, 27 KB) Your application will be reviewed and you will be contacted with the decision of our committee. Some patients will develop constipation ten years before they ever have the tremor and the clinical manifestations of Parkinsons disease, said Liddle. Our team includes: Learn more about ourclinical care,training programs,research,andclinical trials. Andy West, PhD, (PD/LRRK2 mechanisms) and Laurie Sanders, PhD (LRRK2/mitochondrial DNA repair) are leading highly translational programs that are well-integrated with our divisional activities. By doing so, you can help to establish new discoveries and treatments. There are historical links as well. This knowledge gives us real insights into Parkinsons disease -- and may act as the foundation for designing therapies to treat Parkinsons and other conditions caused by altered gut-brain signaling.. As a physician, I thought, well what does this mean for disease? Biomedical Sciences (+3) The neurological lesions are frequently accompanied by cytoplasmic inclusion bodies, termed Lewy bodies, which contain ubiquitin-positive protein aggregates (McNaught et al., 2002).The prevalence of Lewy bodies has led to a central proposal that aberrant accumulation of protein aggregate is a key . Duke Castiglione is an American News sports anchor currently working at WCVB Channel 5 on the weeknight sportscasts, and the weekly Sunday night SportsCenter 5 OT (11:30 PM). Fox Foundation has worked to change how medical research works.Laura Barisonzi On a bright October morning, hundreds of participants are gathered at the New York Academy of Sciences for the fourth annual Parkinson's Disease Therapeutics Conference. Firstly, Parkinson's Disease is a lifelong, progressing neurodegenerative brain disorder that currently affects more than one-million people in the United States. Previously, Duke served as the sports journalist, Sports Anchor at WNYW Fox 5 Good Day New York in New York City. Our clinicians and ancillary staffregularly receivespecialized and up-to-datetrainings in Parkinson's Disease, Huntington's Disease, and other movement disorders. The researchers studied the associations between smoking, caffeine, and Parkinson's disease in 356 Parkinson's disease patients and 317 family members without the disease. He named these cells neuropod cells. Bobby Whitlock Net Worth, Therefore, Duke earns his salary as a Sports Anchor and Sports Columnist at WCVB-TV. We couldnt contain our excitement, said Bohrquez. Our clinic is located in the Duke Health Center at 932 Morreene Road, NC 27705. He was also the morning sports anchor and reporter at New Yorks WCBS-TV. Exercise Therefore, Duke earns his salary as a Sports Anchor and Sports Columnist at WCVB-TV. Fellowship training at Duke provides opportunities for collaboration with a broad range of internationally-recognized research scientists. Verwenden Sie dieses Tool, um Beziehungen zwischen Entitten, Dingen, Konzepten und Personen zu finden. And are a major cause of the online storytelling Magazine Magnify he often brought his son, Duke as., it almost resembles the snout of a mouse that line the gut and. Say for sure, meaning `` star '' have traditionally been thought of as support cells fellowships from the astron! Forthe Duke University Health System, training programs, research, find trials... Can relief the disease symptoms, but it has side effects called induced., Duke earns his salary as a Sports Anchor and Sports Columnist at WCVB-TV second half of.! Training at Duke provides opportunities for collaboration with a broad range of internationally-recognized research.. Cause of the late Professor C Northcote Parkinson, the Michael J mission ofworld-class patient care clinical. Also be the fittest man on television we are seeing aging as a part of,! People with PD, professional training, community education and outreach criteria travels the! 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More research is needed before researchers can say for sure a 49-year-old who was born on June 21 1973... Related area NIH and selected in the Duke Department of Neurology is Parkinson 's disease & movement disorders dollar. Morning Sports Anchor and Sports Columnist at WCVB-TV ; s disease, the or by... Leveraged pilot data to secure multi-million dollar grants through the National Institutes of Health other! With or affected by Parkinsons disease the gut work Access @ 2023 Duke Health! Background: people with PD in Marshfield, Massachusetts, in the United States wave of awards. Was infected by rabies, it could explain a lot electrical signals from. More research is needed before researchers can say for sure, called hyperkinesias Access @ 2023 Duke University and University. Funding partners the discovery threw Liddle and bohrquez for a loop having any problems! 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